─░ndolen Lenfoma

Chlorambucil
Chlorambucil  10 mg po qd

Cyclophosphamide
Cyclophosphamide  100 mg/m2 po qd

Fludarabine
Fludarabine 25 mg/m2 iv qd d1-5 q4w

Rituximab 
Rituximab

Regimen 1
375 mg/m2 iv qw x 4 followed by 375 mg/m2 iv q2m x 4

Regimen 2
375 mg/m2 iv qw x 4 followed by 375 mg/m2 iv qw x 4 every 6 months

Bendamustine

Bendamustine 120 mg/m2 iv over 30-60 min d1 and 2
Q3w x 12 cycles

Oxaliplatin (for MALT lymphoma)
Oxaliplatin  130  mg/m2 iv over 2 hours
Q3w x 6 cycles

CVP

Regimen 1
Cyclophosphamide  750 mg/m2 iv d1
Vincristine 1.4 mg/m2 ( max 2 mg ) iv d1
Prednisone 40 mg/m2 po qd d1-5
Q3w x 8 cycles
 
Regimen 2

Cyclophosphamide  1000 mg/m2 iv d1
Vincristine 1.4 mg/m2 ( max 2 mg ) iv d1
Prednisone 100 mg po qd d1-5
Q3w x 6-8 cycles

R-CVP
Rituximab 375 mg/m2 iv d1
Cyclophosphamide  750 mg/m2 iv d1
Vincristine 1.4 mg/m2 ( max 2 mg ) iv d1
Prednisone 40 mg/m2 po qd d1-5
Q3w x 8 cycles
 
CVP + maintenance R

Cyclophosphamide  1000 mg/m2 iv d1
Vincristine 1.4 mg/m2 ( max 2 mg ) iv d1
Prednisone 100 mg po qd d1-5
Q3w x 6-8 cycles
Followed by
Rituximab 375 mg/m2 iv qw x 4, q6m x 4 (2 years)
 
CHOP
Cyclophophamide (Cytoxan) 750 mg/m2 iv d1
Doxorubicin (Adriamycin) 50 mg/m2 iv d1
Vincristine 1.4 mg/m2 ( max 2 mg ) iv d1
Prednisone 100 mg po qd d1-5
Q3w x 6-8 cycles
 
R-CHOP

Rituximab (Rituxan) 375 mg/m2 iv d1
Cyclophophamide (Cytoxan) 750 mg/m2 iv d1
Doxorubicin (Adriamycin) 50 mg/m2 iv d1
Vincristine 1.4 mg/m2 ( max 2 mg ) iv d1
Prednisone 100 mg po qd d1-5
Q3w x 6-8 cycles
 
R→R-CVP or R-CHOP

Rituximab (Rituxan) 375 mg/m2 iv qw x 4
Followed by
R-CVP or R-CHOP q3w x 3 cycles


R-CHOP + maintenance R

R-CHOP x 6 cycles, followed by Rituximab 375 mg/m2 iv q3m x 2 yrs.

FM
Fludarabine 25 mg/m2 iv qd d1-3
Mitoxantrone 10 mg/m2 iv d1
Q3w

R-FCM
Rituximab  375 mg/m2 iv d0
Fludarabine 25 mg/m2 iv over 30 min qd d1-3
Cyclophosphamide 200 mg/m2 iv over 4 hrs qd d1-3
Mitoxantrone  8 mg/m2 iv over 30 min d1
Q4w x 4 cycles

R-FCM + maintenance R
R-FCM as above, followed by Rituximab  375 mg/m2 iv qw x 4 doses at 3 and 9 months

R-MCP
Rituximab  375 mg/m2 iv d1
Mitoxantrone  8 mg/m2 iv d3-4
Chlorambucil  3 mg/m2 po tid d3-7
Prednisone 25 mg/m2 po qd d3-7
Q4w x 8 cycles.

R-GemOx

Rituximab 375 mg/m2 iv d1
Gemcitabine 1000 mg/m2 (in 500 ml normal saline) iv at 10 mg/m2/min d2
Oxaliplatin  100 mg/m2 iv over 2 hrs d2
Q2w x 8 cycles