MP
Regimen 1
Melphalan 0.15 mg/kg po qd x 7 days
Prednisone 20 mg po tid x 7 days
Q6w
Regimen 2
Melphalan 0.25 mg/kg po qd x 4 days
Prednisone 2 mg/kg po qd x 4 days
Q6w
Regimen 3
Melphalan 9 mg/m2 po qd d1-4
Prednisone 60 mg/m2 po qd d1-4
Q6w x 9 cycles
Dexamethasone
Dexamethasone 40 mg po qd d1-4, 9-12, 17-20 or d1-4 only
Q4-6w
VAD
Vincristine 0.4 mg iv over 30 min qd d1-4
Doxorubicin 9 mg/m2 iv over 30 min qd d1-4
Dexamethasone 40 mg po qd d1-4, 9-12, 17-20
Q4w
DVD
Pegylated liposomal doxorubicin 40 mg/m2 iv d1
Vincristine 2 mg iv d1
Dexamethasone 40 mg po qd d1-4
Q4w
Thal/Dex
Thalidomide 100-200 mg po qd
Dexamethasone 40 mg po qd d1-4, 9-12, 17-20 for odd cycles and d1-4 only for even cycles q4w
Len/Dex low dose
Lenalidomide 25 mg po qd d1-21
Dexamethasone 40 mg po d1, 8, 15, 22
Q4w
Len/Dex high dose
Lenalidomide 25 mg po qd d1-21
Dexamethasone 40 mg po qd d1-4, 9-12, 17-20 for the first 4 cycles, then d1-4 only
Aspirin 81 or 325 mg po qd
Q4w until disease progression
Len+/- Dex
Lenalidomide 30 mg po qd d1-21 q4w
Dexamethasone 40 mg po qd d1-4 q2w
BiRD
Clarithromycin 500 mg po bid beginning on d2 of cycle 1
Lenalidomide 25 mg po qd d3-21 of cycle 1 and d1-21 of subsequent cycles
Dexamethasone 40 mg po d1, 2, 3, 8, 15, and 22 during cycle 1 and then qw
Q4w
ASA 81 mg po qd
Omeprazole 20 mg po qd
Trimethoprim/sulfamethoxazole DS 1 tab po bid 3 times a week
Melphalan + Prednisone + Thalidomide
regimen 1
Melphalan 0.25 mg/kg/d po d1-4 q6w x 12 cycles
Prednisone 2 mg/kg/d po d1-4 q6w x 12 cycles
Thalidomide 100-400 mg po qd
regimen 2
Melphalan 4 mg/m2/d po d1-7 qm x 6 cycles
Prednisone 40 mg/m2/d po d1-7 qm x 6 cycles
Thalidomide 100 mg po qd till disease progression
Prophylactic Enoxaparin 40 mg sc qd during first 4 cycles of therapy
Melphalan + Prednisone + Lenalidomide
Melphalan 0.18 mg/kg po qd d1-4
Prednisone 2 mg/kg po qd d1-4
Lenalidomide 10 mg po qd d1-21
Q4w x 9 cycles
Maintenance Lenalidomide 10 mg po qd d1-21 q4w until progression
Ciprofloxacin 500 mg po bid for antibiotic prophylaxis
Aspirin 100 mg po qd for thrombosis prophylaxis
Maintenance Prednisone
Prednisone 50 mg po qod
Bortezomib
Bortezomib 1.3 mg/m2 iv d1, 4, 8 and 11
Q3w
Bortezomib + Pegylated liposomal doxorubicin
Bortezomib 1.3 mg/m2 iv bolus d1, 4, 8 and 11
Pegylated liposomal doxorubicin (Doxil) 30 mg/m2 iv over 1 h d4
Q3w until progression
PAD
Bortezomib 1.3 mg/m2 iv bolus d1, 4, 8, 11
Dexamethasone (Decadron) 40 mg po d1-4, 8-11, 15-18 of cycle 1, d1-4 of cycles 2-4
Doxorubicin (Adriamycin) 4.5-9 mg/m2 iv qd d1-4
Q3w x 4 cycles
BMP
Bortezomib 1.3 mg/m2 iv bolus d1, 4, 8, 11, 22, 25, 29, 32 q6w x 4 cycles, then d1, 8, 22, 29 q6w x 5 cycles
Melphalan (Alkeran) 9 mg/m2 po qd d1-4 q6w x 9 cycles
Prednisone 60 mg/m2 po qd d1-4 q6w x 9 cycles
VMPT
Bortezomib 1-1.3 mg/m2 iv bolus d1, 4, 15, 22
Melphalan 6 mg/m2 po qd d1-5
Prednisone 60 mg/m2 po qd d1-5
Thalidomide 50 mg po qd
Q35days x 6 cycles
Maintenance thalidomide after ASCT
Regimen 1
Thalidomide 100 mg po qd starting 3 months after ASCT for 6 months
Regimen 2
Thalidomide 400-50 mg po qd
Pamidronate 0 mg iv q4w
BCD
Velcade 1,4,8,11 1,3 mg/m2
Cyclophosphamide 900 mg/ m2 1.gün
Deksametazon 1,2 , 4,5 , 8,9 , 11,12 40mg/gün
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