Chlorambucil
Chlorambucil (Leukeran)10 mg/m2/d po x 7 days or 40 mg/m2 po
Q4w x 12 cycles

Bendamustine
Bendamustine 100 mg/m2 iv over 30 min d1 and 2
Q4w x 6 cycles

Fludarabine
Fludarabine 25 mg/m2/d iv x 5 days or 40 mg/m2/d po x 5 days
Q4w x 6-12 cycles

Cladribine
Cladribine (2-CdA)

Regimen 1
0.1 mg/kg/d civi d1-7 q4-5w

Regimen 2
0.12 mg/kg/d iv over 2 hrs d1-5 q4w x 6 cycles

Rituximab
Rituximab 375 mg/m2 iv qw x 4 wks q6m x 4 courses

Alemtuzumab IV
Premedications:
Diphenhydramine  50 mg po
Acetaminophen  500-1000 mg po
Alemtuzumab start at 3 mg/d iv, increase to 10 mg/d and 30 mg/d as soon as tolerated, then 30 mg/d iv over 2 hours tiw up to 12-16 weeks
Bactrim DS 1 tab po bid tiw
Famciclovir 250 mg po bid

Alemtuzumab (Campath) SC +/- Fludarabine
Alemtuzumab  30 mg/d sc tiw (after dose escalation in first week) x 24 wks
Add Fludarabine 40 mg/m2/d po for 3 days q4w for patients failing to response to alemtuzumab
Acyclovir and cotrimoxazole prophylaxis

Chlorambucil + Prednisone
Chlorambucil 30 mg/m2 po d1
Prednisone 80 mg po qd d1-5
Q2w

Fludarabine + Prednisone
Fludarabine 30 mg/m2/d iv d1-5
Prednisone 30 mg/m2/d po d1-5
Q4w

Fludarabine + Cyclophosphamide (FC)
 
IV regimen 1
Fludarabine 25-30 mg/m2/d iv d1-3
Cyclophosphamide  250 mg/m2/d iv d1-3
Q4w x 6 cycles

IV regimen 2
Fludarabine 20 mg/m2/d iv d1-5
Cyclophosphamide 600 mg/m2 iv d1
Q4w x 6 cycles

PO regimen
Fludarabine 24 mg/m2/d po d1-5
Cyclophosphamide 150 mg/m2/d po d1-5
Q4w x 6 cycles

Fludarabine + Rituximab
Fludarabine 25 mg/m2/d iv d1-5
Rituximab  375 mg/m2 iv d1 and 4 of cycle 1, then d1 only for cycles 2-6
Q4w x 6 cycles
2 months later:
Rituximab 375 mg/m2 iv qw x 4 doses

Fludarabine + Cyclophosphamide + Rituximab (FCR)
Fludarabine 25 mg/m2/d iv d1-3
Cyclophosphamide  250 mg/m2/d iv d1-3
Rituximab 375 mg/m2 iv d1 cycle 1 and 500 mg/m2 iv d1 cycle 2-6
Q4w x 6 cycles
Allopurinol 300 mg po qd d1-7 cycle 1
Bactrim DS 1 po bid twice a week
Valacyclovir 500 mg po qd

Cladribine + Mitoxantrone + Cyclophosphamide (CMC)
Cladribine (2-CdA) 0.12 mg/kg/d iv over 2 hrs d1-3
Mitoxantrone 10 mg/m2 iv d1
Cyclophosphamide  650 mg/m2 iv d1
Q4w x 6 cycles
 
CVP
Cyclophosphamide  300 mg/m2/d po d1-5
Vincristine 1.4 mg/m2 (max 2 mg) iv d1
Prednisone 100 mg/m2/d po d1-5
Q3w up to 18 months

Lenalidomide 

Regimen 1
Lenalidomide  5 mg po qd, escalate by 5 mg every 1-2 weeks to 25 mg po qd d1-21 q4w until molecular CR or unacceptable toxicity
Allopurinol 300 mg po qd for 14 days starting 2-3 days before lenalidomide

Regimen 2
Lenalidomide 10 mg po qd for 28 days, then increase by 5 mg every 28 days to 25 mg qd until progression or unacceptable toxicity).

Lenalidomide + Rituximab
Lenalidomide 25 mg po qd d1-21
Rituximab  375 mg/m2 iv d1, 8 and 15 of cycle 1, then d1 and 15 of cycles 2-6
Q4w

Pentostatin + Cyclophosphamide + Rituximab (PCR)

Regimen 1
Pentostatin 2 mg/m2 iv d1 cycles 1-6
Cyclophosphamide  600 mg/m2 iv d1 cycles 1-6
Rituximab 100 mg/m2 iv d1 and 375 mg/m2 d3 and 5 for cycle 1, then 375 mg/m2 d1 for cycles 2-6
Q3w x 6 cycles
Allopurinol 300 mg po qd d1-15 cycle 1
Filgrastim support
Bactrim DS 1 po bid tiw x 1 year
Acyclovir 800 mg po bid x 1 year

Regimen 2
Pentostatin 4 mg/m2 iv d1 cycles 1-6
Cyclophosphamide  600 mg/m2 iv d1 cycles 1-6
Rituximab  375 mg/m2 iv d1 cycles 2-6
Q3w x 6 cycles
Filgrastim support
Bactrim DS 1 po bid tiw
Acyclovir 800 mg po bid

Cyclophosphamide + Fludarabine + Alemtuzumab + Rituximab (CFAR)

Cyclophosphamide 250 mg/m2/d iv d3-5
Fludarabine 25 mg/m2/d iv d3-5
Alemtuzumab  30 mg iv d1, 3 and 5
Rituximab  375-500 mg/m2 iv d2
Q4w x 6 cycles
Allopurinol 300 mg po qd d1-7 cycle 1
Pegfilgrastim support
Bactrim DS 1 po bid tiw till 2 months after chemoimmunotherapy
Valganciclovir till 2 months after chemoimmunotherapy